4-benzyloxy-2-methoxy-1-methyl-1H-benzimidazole → 4-hydroxy-2-methoxy-1-methyl-1H-benzimidazole

HRID 1699168Notes

Reaction equation

HRID 1699168 reaction equation
C([O:8][C:9]1[C:17]2[N:16]=[C:15]([O:18][CH3:19])[N:14]([CH3:20])[C:13]=2[CH:12]=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[C:17]2[N:16]=[C:15]([O:18][CH3:19])[N:14]([CH3:20])[C:13]=2[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 107543614-benzyloxy-2-methoxy-1-methyl-1H-benzimidazole

Product 1

HCID 106548994-hydroxy-2-methoxy-1-methyl-1H-benzimidazoleYield 34.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-benzyloxy-2-methoxy-1-methyl-1H-benzimidazole (254.8 mg) and 10% palladium on carbon (25 mg) in methanol (2.5 ml) was stirred for 7 hours at ambient temperature under hydrogen atmosphere. Insoluble material was filtered off, and the filtrate was concentrated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate:n-hexane=3:1, V/V) to give 4-hydroxy-2-methoxy-1-methyl-1H-benzimidazole (58.7 mg).

Workup

  1. filtrationInsoluble material was filtered off
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was purified by column chromatography on silica gel (ethyl acetate:n-hexane=3:1, V/V)

Sources & evidence

ORD record
ord-80f26663a8a64e3d85ea0e7a4f05f617
Source dataset
uspto-grants-2002_02
Patent number
US06344462B1

Reaction notes

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