反应详情

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (10 g), acetic anhydride (10.3 g) and pyridine (10.7 g) in anhydrous dichloromethane (100 ml) was stirred for 1 hour at ambient temperature and allowed to stand overnight. The mixture was washed with water, and the organic layer was separated. The aqueous layer was neutralized with sodium bicarbonate and extracted with chloroform. The combined organic layers were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo to give 8-acetoxy-2-methylimidazo[1,2-a]pyridine (13.1 g) as oil.

1. waitto stand overnight
2. washThe mixture was washed with water
3. customthe organic layer was separated
4. extractionextracted with chloroform
5. washThe combined organic layers were washed with saturated sodium bicarbonate solution
6. dry with materialdried over magnesium sulfate
7. customevaporated in vacuo