3,4-dihydro-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-pyrido[2,3-d]-pyrimidinone → 3-Piperidin-4-yl-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

HRID 1699233Notes

Reaction equation

HRID 1699233 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][C:18]4[CH:20]=[CH:21][CH:22]=[N:23][C:17]=4[NH:16][C:15]3=[O:24])[CH2:10][CH2:9]2)C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:19][C:18]3[CH:20]=[CH:21][CH:22]=[N:23][C:17]=3[NH:16][C:15]2=[O:24])[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 183214893,4-dihydro-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-pyrido[2,3-d]-pyrimidinoneHCID 178418361HCID 178418361, compound

Product 1

HCID 222932273-Piperidin-4-yl-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4.7 g (0.0146 mol) of 3,4-dihydro-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-pyrido[2,3-d]-pyrimidinone in 50 ml of methanol was hydrogenated at a temperature of 50° C. and in the presence of 2.0 g of 20% palladium/charcoal until the uptake of hydrogen ceased. After removal of the catalyst and solvent 3.3 g (97.3% of theory) of a colourless oil of Rf=0.35 (FM1) were obtained.

Workup

  1. customAfter removal of the catalyst and solvent 3.3 g (97.3% of theory) of a colourless oil of Rf=0.35 (FM1)
  2. customwere obtained

Sources & evidence

ORD record
ord-15f9dcbfaf284779a6554f3fc4c49a25
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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