HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1699234Generated: November 2, 2026
Dimethylformamide dimethyl acetal → (E)-Methyl 4-(2-(dimethylamino)vinyl)-3-nitrobenzoate
https://huagongshe.com/reaction/1699234
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Methyl 4-methyl-3-nitrobenzoate | HCID 81816 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (E)-Methyl 4-(2-(dimethylamino)vinyl)-3-nitrobenzoate | HCID 894337 | — |
Reaction Steps
A mixture of 98.3 g (0.504 mol) of methyl 4-methyl-3-nitrobenzoate, 78.0 g (0.655 mol) of N,N-dimethylformamide dimethylacetal and 1 1 of dimethylformamide was heated to 140° C. for 3 hours. The solvent was distilled off in vacuo, the residue was triturated thoroughly with 1 1 methanol. After drying in vacuo 119.5 g (94.7% of theory) of a red amorphous substance was obtained, which was further processed without any more purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06344449B1 |
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| Source dataset | uspto-grants-2002_02 |
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| ORD ID | ord-beb17efab9a54ca883081cdb86f2d74d |
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| Source note | uspto-grants-2002_02 |
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