HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3,4-dihydro-3-[1-(4-piperidinyl)-4-piperidinyl]-2(1H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-dihydro-3-[1-[1-(phenylmethyl)-4-piperidinyl]-4-piperidinyl]-2(1H)-quinazolinone | HCID 18321174 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Dichloromethane cyclohexane methanol | HCID 69163855 | — |
| Product | 3,4-dihydro-3-[1-(4-piperidinyl)-4-piperidinyl]-2(1H)-quinazolinone | HCID 18321434 | 92% |
Reaction Steps
Prepared analogously to Example A3f) from 3,4-dihydro-3-[1-[1-(phenylmethyl)-4-piperidinyl]-4-piperidinyl]-2(1H)-quinazolinone by hydrogenolysis, but using Pearlman's catalyst, in a yield of 92% of theory. Colourless crystals, Rf=0.48 (Macherey-Nagel, POLYGRAM® SIL G/UV254 ready-made films for TLC; eluant: dichloromethane/methanol/cyclohexane/conc. ammonia 68/20/10/5 v/v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06344449B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-aee8c57ba1174fadb5b61c90de0f3795 |
| Source note | uspto-grants-2002_02 |