3-(1-benzylpiperidin-4-yl)-3,4-dihydro-1H-2$l^{6},1,3-benzothiadiazine-2,2-dione → 3-(piperidin-4-yl)-3,4-dihydro-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide

HRID 1699251Notes

Reaction equation

HRID 1699251 reaction equation
[O:1]=[S:2]1(=[O:25])[N:7]([CH:8]2[CH2:13][CH2:12][N:11](CC3C=CC=CC=3)[CH2:10][CH2:9]2)[CH2:6][C:5]2[CH:21]=[CH:22][CH:23]=[CH:24][C:4]=2[NH:3]1>[Pd]>[O:25]=[S:2]1(=[O:1])[N:7]([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH2:6][C:5]2[CH:21]=[CH:22][CH:23]=[CH:24][C:4]=2[NH:3]1

Participants

3

Reactant 1

HCID 131172113-(1-benzylpiperidin-4-yl)-3,4-dihydro-1H-2$l^{6},1,3-benzothiadiazine-2,2-dione

Product 1

HCID 131172133-(piperidin-4-yl)-3,4-dihydro-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared analogously to Example A3f) from 3,4-dihydro-2,2-dioxido-3-[1-(phenylmethyl)-4-piperidinyl]-2,1,3-benzothiadiazine by catalytic hydrogenation in the presence of palladium/charcoal in a quantitative yield. Colourless, amorphous substance.

Sources & evidence

ORD record
ord-285d8d15f9574a7f80133ecab435443d
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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