Cyclohexanone → 1-(1,1-Dimethylethoxycarbonyl)-4-(1-cyclohexyl-4-piperidinyl)piperazine

HRID 1699258Notes

Reaction equation

[CH3:1][C:2]([CH3:19])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH2:9][CH2:8]1)=[O:6])[CH3:3].[C:20]1(=O)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:3][C:2]([CH3:19])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:14][CH2:15][N:16]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:17][CH2:18]2)[CH2:9][CH2:8]1)=[O:6])[CH3:1]

Participants

Reactant 2

HCID 7967Cyclohexanone

HCID 17750356tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 183210841-(1,1-Dimethylethoxycarbonyl)-4-(1-cyclohexyl-4-piperidinyl)piperazineYield 99%

Procedure

Prepared analogously to Example A19a) from 1-(1,1-dimethylethoxycarbonyl)-4-(4-piperidinyl)piperazine and cyclohexanone in a yield of 99% of theory. Colourless, highly viscous oil.

Sources & evidence

ORD record: ord-dd6885090649439cbeaa4dce1f2d8690
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06344449B1

Reaction notes

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