N,N-Dimethylethylenediamine → HCID 18319613, compound

Participants

Reaction Steps

To a mixture of 9-carboxy-2,3-dihydro-1-benzoxepin-4-carboxylate (0.39 g), N,N-dimethylethylenediamine (0.163 ml), and 1-hydroxybenzotriaole hydrate (0.22 g) in dichloromethane (8 ml) was added 1-(3-dimethylamino-propyl)-3-ethylcarbodiimide hydrochloride (0.31 g). The reaction mixture was stirred for 4.5 hours at ambient temperature and evaporated in vacuo. The residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was washed successively with water and brine, dried over anhydrous magnesium sulfate, and evaporated in vacuo to give a solid of ethyl 2,3-dihydro-9-[2-(N,N-dimethylamino)-ethylaminocarbonyl]-1-benzoxepin-4-carboxylate (0.39 g),

Provenance & Evidence