Pyridine → HCID 18319513, compound

Participants

Reaction Steps

Under nitrogen atmosphere, phosphorus pentachloride (1.6 g) was added to a mixture of methyl 2,3-dihydro-9-hydroxymethyl-1-benzoxepin-4-carboxylate (1.2 g) and pyridine (0.62 ml) in dichloromethane (24 ml) under ice-cooling and the mixture was stirred at the same temperature for 2 hours. To the reaction mixture was added a mixture of ethyl acetate and water. The separated organic layer was washed with saturated aqueous sodium bicarbonate and water. The organic layer was dried over magnesium sulfate and evaporated in vacuo to give methyl 2,3-dihydro-9-chloromethyl-1-benzoxepin-4-carboxylate (1.19 g) as an oil.

Provenance & Evidence