Hydrochloric Acid → HCID 178513047, compound

Participants

Reaction Steps

Under nitrogen atmosphere, 28% sodium methoxide in methanol (5.5 ml) was added to a solution of methyl 2,3-dihydro-9-carboxy-1-benzoxepin-4-carboxylate (1.5 g) and guanidine hydrochloride (2.9 g) in N,N-dimethylformamide (15 ml) at ambient temperature. The mixture was stirred at the same temperature for 18 hours. The reaction mixture was poured into water and the mixture was adjusted to pH 6.5 with 6N hydrochloric acid. The isolated precipitate was collected by filtration to give (2,3-dihydro-9-carboxy-1-benzoxepin-4-carbonyl)guanidine (1.11 g).

Provenance & Evidence