Guanidine Hydrochloride → HCID 178453694, compound

Participants

Reaction Steps

To a mixture of methyl 2,3-dihydro-9-[2-(tert-butoxycarbonylamino)ethylaminocarbonyl]-1-benzoxepin-4-carboxylate (1.1 g) and guanidine hydrochloride (1.3 g) in N,N-dimethylformamide (11 ml) was added 28% sodium methoxide in methanol (2.6 ml). The reaction mixture was stirred for 8 hours at ambient temperature, and the mixture was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo to give {2,3-dihydro-9-[2-(tert-butoxycarbonylamino)ethylaminocarbonyl]-1-benzoxepin-4-carbonyl}guanidine (0.9 g) as an oil.

Provenance & Evidence