2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → 2-{4-[4-(4,5-Dichloro-2-methlylimidazol-1-yl)butyl]piperazin-1-yl}-5-fluoropyrimidine citrate

Participants

Reaction Steps

1.1 g (5.2 mmol) of citric acid monohydrate are added to a solution of 2 g (5.2 mol) of 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]piperazin-1-yl}-5-fluoropyrimidine in absolute ethanol. After a certain period of time, 2.72 g (91% yield) of 2-{4-[4-(4,5-dichloro-2-methlylimidazol-1-yl)butyl]piperazin-1-yl}-5-fluoropyrimidine citrate precipitate in the form of a solid with an M.p. of 151-153° C.

Provenance & Evidence