4-Methoxybenzenethiol → HCID 18320783, compound

HRID 1699462Notes

Reaction equation

HRID 1699462 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[C:10]12([C:20](=O)[CH2:21][C:22](OCC)=[O:23])[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][CH:12]([CH2:13]3)[CH2:11]1)[CH2:17]2>>[C:10]12([C:20]3[S:9][C:6]4[C:7]([C:22](=[O:23])[CH:21]=3)=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[CH2:17][CH:16]3[CH2:15][CH:14]([CH2:13][CH:12]([CH2:18]3)[CH2:11]1)[CH2:19]2

Participants

3

Reactant 2

HCID 127654-MethoxybenzenethiolHCID 86861Ethyl beta-tricyclo(3.3.1.13,7)decyl-beta-oxopropionate

Product 1

HCID 18320783HCID 18320783, compound

Procedure

1.4 g 4-methoxythiophenol is added to 10 g of polyphosphoric acid preheated to about 90°. Then 2.5 g ethyl 3-(1-adamantyl)-3-oxopropionate is added slowly, and the mixture is stirred for altogether 1.5 hours at 90°. The mixture is poured onto ice/water, vigorously stirred and extracted with ethyl acetate. The combined organic layers are dried over magnesium sulfate and evaporated in vacuo. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 6/1). 2-(1-adamantyl)-6-methoxy-4H-thiochromen-4-one is obtained (colourless crystals; mp 140°). b) Under argon 14 ml of 1M boron tribromide solution in dichloromethane are added at room temperature to a solution of 1.12 g 2-(1-adamantyl)-6-methoxy-4H-thiochromen-4-one in dry dichloromethane. After stirring for 1 hour the mixture is poured onto ice/water and extracted with dichloromethane. The combined organic layers are washed with aqueous sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo. The title compound is obtained (colourless crystals; mp 257° after chromatography on silica gel using cyclohexane/ethyl acetate 4/1 as an eluant).

Workup

  1. custompreheated to about 90°
  2. additionThe mixture is poured onto ice/water
  3. stirringvigorously stirred
  4. extractionextracted with ethyl acetate
  5. dry with materialThe combined organic layers are dried over magnesium sulfate
  6. customevaporated in vacuo
  7. customThe residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 6/1)

Sources & evidence

ORD record
ord-286723c64f5745fbbb443eca54621d01
Source dataset
uspto-grants-2002_02
Patent number
US06346626B1

Reaction notes

Loading…