3,5-Dimethylbenzoyl Chloride → HCID 86757780, compound

HRID 1699472Notes

Reaction equation

HRID 1699472 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](Cl)=[O:6].[NH2:12][CH:13]1[CH2:18][CH2:17][N:16]([C@@H:19]2[CH2:24][CH2:23][N:22]([C:25](=[O:34])[C:26]3[CH:31]=[C:30]([CH3:32])[CH:29]=[C:28]([CH3:33])[CH:27]=3)[C@@H:21]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:20]2)[CH2:15][CH2:14]1>>[CH3:32][C:30]1[CH:31]=[C:26]([CH:27]=[C:28]([CH3:33])[CH:29]=1)[C:25]([N:22]1[CH2:23][CH2:24][C@@H:19]([N:16]2[CH2:17][CH2:18][CH:13]([NH:12][C:5](=[O:6])[C:4]3[CH:8]=[C:9]([CH3:11])[CH:10]=[C:2]([CH3:1])[CH:3]=3)[CH2:14][CH2:15]2)[CH2:20][C@@H:21]1[CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:34]

Participants

3

Reactant 2

HCID 810883,5-Dimethylbenzoyl ChlorideHCID 86757781HCID 86757781, compound

Product 1

HCID 86757780HCID 86757780, compound

Procedure

Using the same reaction procedure as described in example B6, 3,5-dimethylbenzoyl chloride was reacted with compound 22 to form (±)-trans-N-[1-[1-(3,5-dimethylbenzoyl)-2-(phenylmethyl)-4-piperidinyl]-4-piperidinyl]-3,5-dimethylbenzamide (compound 21, mp. 120.1° C.).

Workup

  1. customthe same reaction procedure

Sources & evidence

ORD record
ord-850619c967ab48fa84c38739df7d0c4a
Source dataset
uspto-grants-2002_02
Patent number
US06346540B1

Reaction notes

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