Propionyl chloride → HCID 86756199, compound

HRID 1699473Notes

Reaction equation

[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[O:6]=[C:7]1[N:11]([CH:12]2[CH2:17][CH2:16][N:15]([C@H:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:33])[C:25]4[CH:30]=[C:29]([CH3:31])[CH:28]=[C:27]([CH3:32])[CH:26]=4)[C@@H:20]([CH2:34][C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:19]3)[CH2:14][CH2:13]2)[C:10]2[CH:41]=[CH:42][CH:43]=[CH:44][C:9]=2[NH:8]1>>[CH3:31][C:29]1[CH:30]=[C:25]([CH:26]=[C:27]([CH3:32])[CH:28]=1)[C:24]([N:21]1[CH2:22][CH2:23][C@H:18]([N:15]2[CH2:14][CH2:13][CH:12]([N:11]3[C:10]4[CH:41]=[CH:42][CH:43]=[CH:44][C:9]=4[N:8]([C:1](=[O:4])[CH2:2][CH3:3])[C:7]3=[O:6])[CH2:17][CH2:16]2)[CH2:19][C@@H:20]1[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:33]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 86756200HCID 86756200, compound

Product 1

HCID 86756199HCID 86756199, compound

Procedure

Using the same reaction procedure as described in example B6, propionyl chloride was reacted with (±)-cis-4-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(3,5-dimethylbenzoyl)-2-(phenylmethyl)piperidine to form (±)-cis-1-[1-[1-(3,5-di-methylbenzoyl)-2-(phenyl-methyl)-4-piperidinyl]-4-piperidinyl]-1,3-dihydro-3-(1-oxopropyl)-2H-benzimidazol-2-one (compound 34).

Workup

customthe same reaction procedure

Sources & evidence

ORD record: ord-842dcb430d864e6cb0d20c2732ca0c49
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06346540B1

Reaction notes

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