Water → Dihydroartemisinin ethyl ether

Participants

Reaction Steps

Dihydroartemisinin (50 mg) was dissolved in 3 ml dry ethanol with stirring the solution for 10 min. at room temperature and add cation exchange resin (Dowex-50, 50 mg) and triethylorthoformate (4 ml) in the solution. The reaction mixture is stirred for 10 hrs at room temperature (30° C.). Water was added in the reaction mixture and filters the cation exchange resin. The reaction product was extracted by dichloromethane. The organic layer was separated, dried over anhydrous sodium sulphate and evaporated under vacuum to yield pure arteether (50 mg).

Provenance & Evidence