p-Hydroxyaniline mustard → HCID 9805671, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5, 3-(3-allyl-2,5-dimethyl-1,4-benzoquinonyl)-3-methylbutyric acid was reacted with 4-[bis(2-chloroethyl)amino]phenol to give 4-[bis(2-chloroethyl)amino]phenyl 3-(3-allyl-2,5-dimethyl-1,4-benzoquinonyl)-3-methylbutyrate as an oil in 26% yield; NMR Spectrum: (CDCl3) 1.52 (s, 6H), 1.96 (s, 3H), 2.17 (s, 3H), 3.15 (d, 2H), 3.2 (s, 2H), 3.56-3.72 (m, 8H), 4.99 (m, 2H), 5.72 (m, 1H), 6.58-6.88 (m, 4H); Mass Spectrum: (M+H+) 496,494,492.

Provenance & Evidence