p-Hydroxyaniline mustard → HCID 57207800, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5, 3-(2,5-dimethyl-3-propyl-1,4-benzoquinonyl)-3-methylbutyric acid was reacted with 4-[bis(2-chloroethyl)amino]phenol to give 4-[bis(2-chloroethyl)amino]phenyl 3-(2,5-dimethyl-3-propyl-1,4-benzoquinonyl)-3-methylbutyrate in 32% yield; NMR Spectrum: (CDCl3) 0.91 (t, 3H), 1.39 (m, 2H), 1.52 (s, 6H), 1.95 (s, 3H), 2.18 (s, 3H), 2.35 (t, 2H), 3.2 (s, 2H), 3.55-3.73 (m, 8H), 6.6 (d, 2H), 6.84 (d, 2H); Mass Spectrum: (M+H+) 498, 496, 494.

Provenance & Evidence