HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 582531, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1H-Indole-3-propanamide, alpha-amino-, hydrochloride (1:1), (alphaS)- | HCID 6452180 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 582531 | HCID 582531 | — |
Reaction Steps
To a solution of 8.35 g (0.21 mol) NaOH in 100 ml of water was added 200 ml of THF followed by 25.0 g (0.104 mol) of L-tryptophanamide hydrochloride. The mixture was cooled on ice and 19.6 g (0.114 mol) of benzylchloroformate was added under vigorous stirring during 5 minutes. The ice bath was removed and the mixture was stirred for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06346625B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-6f53bb2531934cd5a10d9015f3c1c289 |
| Source note | uspto-grants-2002_02 |