HCID 18320744, compound → HCID 18320732, compound

Participants

Reaction Conditions

Reaction Steps

To 0.10 g (0.16 mmol) of the product of step f) was added 10 ml of a solution of TMS-polyphosphate (Yokoyama et al. Synthesis (1982) 591-592) in CH2Cl2. The flask was sealed and heated on an oil bath to 50° C. for 3 hours. The organic phase was diluted to 20 ml with CH2Cl2 and then washed with 10 ml of water, 5 ml of 1M sulfuric acid and finally with 5 ml of brine. The organic phase was evaporated, and the residue was purified by chromatography on silica (CH2Cl2:MeOH 97:3), furnishing 65 mg (67%) of the sub-title product.

Provenance & Evidence