Potassium Carbonate → 3-{3-[5-Cyano-1-(2,4-dimethoxybenzyl)-3-(3-indolyl)-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-1-indolyl}-propyl methanesulfonate

Participants

Reaction Conditions

Reaction Steps

To a solution 0.15 g (0.298 mmol) of the product from step b) in 2 ml of DMF was 0.40 g (1.72 mmol) of 1,3-propandiol bismethansulfonate and 0.50 g (3.62 mmol) of K2CO3. The mixture was stirred at 70° C. overnight and partitioned between EtOAc and water. The organic phase was washed with water and brine and finally evaporated. The residue was purified by chromatography on silica furnishing 0.11 g (59%) of the sub-title compound.

Provenance & Evidence