Acetic Acid → HCID 18320684, compound

Participants

Reaction Steps

To a suspension of 0.26 g (0.41 mmol) of the product from step b) in 5 ml of DMF was added 0.27 g (4.1 mmol) zinc powder, 0.028 g (0.12 mmol) of cadmium chloride and 5 ml of acetic acid. The mixture was sonicated for 2 minutes and stirred at room temperature for 30 minutes. Water and ethyl acetate were added, the phases were separated and the organic phase washed with saturated NaHCO3(aq), dried over Na2SO4 and evaporated. The residue was purified by chromatography on SiO2 (toluene:ethyl acetate) fuishing the sub-title compound (150 mg, 80%).

Provenance & Evidence