反应详情

In 20 ml of ethanol were suspended 367 mg of 3′,4′-dihydroxy-2-chloroacetophenone and 430 mg of 3,4-dimethoxythiobenzamide. The suspension was refluxed for 3 hours with heating. After cooling, the resulting crystals were collected by filtration, ethanol-washed and dried. The dried material was recrystallized from ethinol to obtain 160 mg of 2-(3,4-dimethoxyphenyl)-4-(3,4-dihydroxyphenyl) thiazole hydrochloride as yellow acicular crystals.

1. temperatureThe suspension was refluxed for 3 hours
2. temperaturewith heating
3. temperatureAfter cooling
4. filtrationthe resulting crystals were collected by filtration, ethanol-
5. washwashed
6. customdried
7. customThe dried material was recrystallized from ethinol