3,4-Diethoxybenzene-1-carbothioamide → 2-(3,4-Diethoxyphenyl)-4-(4-carboxy-2-pyrrolyl)thiazole

HRID 1699588Notes

Reaction equation

HRID 1699588 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:11](=O)[CH2:12]Br)[NH:9][CH:10]=1)=[O:5])C.[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[C:21]([NH2:23])=[S:22])[CH3:16]>>[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([C:21]2[S:22][CH:12]=[C:11]([C:8]3[NH:9][CH:10]=[C:6]([C:4]([OH:3])=[O:5])[CH:7]=3)[N:23]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[CH3:16]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 187071214-Ethoxycarbonyl-2-(alpha-bromoacetyl)pyrrole

Product 1

HCID 187073372-(3,4-Diethoxyphenyl)-4-(4-carboxy-2-pyrrolyl)thiazole

Procedure

4-Ethoxycarbonyl-2-(α-bromoacetyl)pyrrole and 3,4-diethoxythiobenzamide were subjected to the same reaction as in Example 1 and then to the same hydrolysis as in Example 147 to obtain 2-(3,4-diethoxyphenyl)-4-(4-carboxy-2-pyrrolyl)thiazole.

Workup

  1. customto the same hydrolysis as in Example 147

Sources & evidence

ORD record
ord-3578debceb3c4c8fb15d08099664ee62
Source dataset
uspto-grants-2002_02
Patent number
USRE037556E1

Reaction notes

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