Methanol → Tert-butyl 4-(5-amino-3-chloropyridin-2-yl)piperazine-1-carboxylate

HRID 169959Notes

Reaction equation

HRID 169959 reaction equation
[BH4-:24].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([N+:21]([O-:22])=[O:23])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1.[CH3:26][OH:27].[Na+:25].[Ni:34]([Cl:35])[Cl:36].[OH2:28].[OH2:29].[OH2:30].[OH2:31].[OH2:32].[OH2:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([NH2:21])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 962Water6×HCID 24385Nickel DichlorideHCID 28123BorohydrideHCID 685401434-(3-Chloro-5-nitro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 68536999Tert-butyl 4-(5-amino-3-chloropyridin-2-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-9d4bcbfb70e0400fb86ef7cceed5d860
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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