Hydrochloric Acid → HCID 18680830, compound

Participants

Reaction Steps

To an ethanol (4 ml) solution of 2-benzyl-6-ethoxycarbonyl-1-methylbenzimidazole (0.340 g), 5% sodium hydroxide aqueous solution (2.8 g) is added, and the solution is refluxed by heating for 1.5 hours. The solution is made acidic using 1N hydrochloric acid and concentrated under reduced pressure. Ethanol is added to the residue and organic materials are extracted. The ethanol is removed under reduced pressure and thus, 2-benzyl-6-carboxy-1-methylbenzimidazole hydrochloride (0.300 g) is obtained. 1H-NMR (DMSO-d6, δ): 4.00 (3H, s), 4.62 (2H, s), 7.33 (1H, m), 7.35-7.45 (4H, m), 7.83 (1H, d, J=8.4 Hz), 8.06 (1H, d, J=8.4 Hz), 8.42 (1H, s), 13.3 (1H, br s).

Provenance & Evidence