1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 18681029, compound

Participants

Reaction Steps

A methanol (7 ml) solution of N-benzenesulfonyl-4-acetylamino-3-aminobenzamide (0.50 g), 4-(trifluoromethyl)benzyl bromide (0.418 g) and potassium bicarbonate (0.423 g) is stirred for 1 hour at 60° C. to give preliminarily purified N-benzenesulfonyl-4-acetylamino-3-[4-(trifluoromethyl)benzylamino]benzamide (0.30 g). This is dissolved in methanol. When it is left undisturbed crystals precipitated. The crystals are separated through filtration, dried and thus, 6-benzenesulfonylcarbamoyl-2-methyl-1-[4-(trifluoromethyl)benzyl]benzimidazole (0.160 g)is obtained.

Provenance & Evidence