4-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-one → 5-[[3-Fluoro-4-[4-[[2-hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione

HRID 169967Notes

Reaction equation

HRID 169967 reaction equation
[F:17][c:18]1[cH:19][c:20]([CH:21]=[C:22]2[C:23](=[O:28])[NH:24][C:25](=[O:27])[S:26]2)[cH:29][cH:30][c:31]1[N:32]1[CH2:33][CH2:34][C:35](=[O:38])[CH2:36][CH2:37]1.[NH2:1][CH2:2][CH:3]([CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]2[nH:11][c:12](=[O:15])[nH:13][c:14]12)[OH:16]>>[NH:1]([CH2:2][CH:3]([CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]2[nH:11][c:12](=[O:15])[nH:13][c:14]12)[OH:16])[CH:35]1[CH2:34][CH2:33][N:32]([c:31]2[c:18]([F:17])[cH:19][c:20]([CH:21]=[C:22]3[C:23](=[O:28])[NH:24][C:25](=[O:27])[S:26]3)[cH:29][cH:30]2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 158962374-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-oneHCID 738767205-[3-Fluoro-4-(4-oxo-piperidin-1-yl)-benzylidene]-thiazolidine-2,4-dione

Product 1

HCID 1732440475-[[3-Fluoro-4-[4-[[2-hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione

Sources & evidence

ORD record
ord-4d08b752369a403092b2cf72b8dc5698
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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