Acetic Anhydride → HCID 86585695, compound

HRID 1699697Notes

Reaction equation

CC(O)C[C:4]1[N:5]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1.[C:22]([O:25][C:26](=O)[CH3:27])(=[O:24])[CH3:23]>>[CH3:22][CH:17]([N:5]1[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=[CH:4]1)[CH:18]([CH3:19])[CH3:20].[C:22]([O:25][CH2:26][CH3:27])(=[O:24])[CH3:23]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 15224433HCID 15224433, compound

Product 1

HCID 86585695HCID 86585695, compound

Procedure

Using the general method of Example 46, α-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]-quinoline-2-ethanol (9.4 g, 33 mmol, Example 74) was reacted with acetic anhydride to provide the desired product. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Sources & evidence

ORD record: ord-136b27c7323641f4bf35879eee1975f5
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06348462B1

Reaction notes

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