HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1699761Generated: November 1, 2026
Toluene → tert-butyl 5-(1-methyl-3-fluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbamate
https://huagongshe.com/reaction/1699761
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 5-(1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid | HCID 2775668 | — |
| Reactant | N,N,2-Triethylaniline | HCID 18366426 | — |
| Product | tert-butyl 5-(1-methyl-3-fluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbamate | HCID 18369591 | — |
Reaction Steps
A mixture of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid, diphenylphosphoryl azide, triethylamline and toluene was stirred at 50° C. for 30 minutes. Then, tert-butanol was added to the reaction solution. After stirring at 80° C. for 5 hours, it was subjected to purification in the usual way to give tert-butyl 5-(1-methyl-3-fluoromethyl-1H-pyrazol-5-yl)thiophene-2-carbamate as light yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06348480B1 |
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| Source dataset | uspto-grants-2002_02 |
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| ORD ID | ord-72df664ae8ac4d13863834696bd4ed86 |
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| Source note | uspto-grants-2002_02 |
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