Methanol → HCID 22388536, compound

HRID 1699856Notes

Reaction equation

HRID 1699856 reaction equation
[C:1]([C:4]1[C:9]2[S:10][CH:11]=[C:12]([CH2:13][CH3:14])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH3:20]O>>[CH2:13]([C:12]1[C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([C:1]([O:3][CH3:20])=[O:2])[C:9]=2[S:10][CH:11]=1)[CH3:14]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 22388390HCID 22388390, compound

Product 1

HCID 22388536HCID 22388536, compound

Procedure

7-Carboxy-3-ethylbenzo[b]thiophene (3.20 g) and concentrated sulfuric acid were stirred in methanol (100 ml) at 60° C. for 16 hr. The reaction mixture was concentrated and chloroform mixture was added thereto. The mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate. The chloroform was separated, and the residue was dried over magnesium sulfate, and concentrated to give the objective compound (3.04 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionchloroform mixture was added
  3. washThe mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate
  4. customThe chloroform was separated
  5. dry with materialthe residue was dried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d7f85f34dbad48cfac6425f63721efe4
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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