Sulfuric Acid → HCID 22387822, compound

HRID 1699883Notes

Reaction equation

HRID 1699883 reaction equation
[C:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:24])[N:9]=[C:10]([CH3:23])[N:11]2[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:6][CH:5]=1)(=[O:3])N.S(=O)(=O)(O)[OH:26]>O>[C:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:24])[N:9]=[C:10]([CH3:23])[N:11]2[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:6][CH:5]=1)([OH:3])=[O:26]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22388387HCID 22388387, compound

Product 1

HCID 22387822HCID 22387822, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

7-Carbamoyl-1-(2,4-dichlorobenzyl)-2-methyl-4(1H)-quinazolinone (1.40 g) in a mixture of concentrated sulfuric acid (6 ml) and water (6 ml) was heated at 100° C. for 1 hr. After cooling, the precipitated solid was collected by filtration, washed with water, dried and concentrated to give the object compound (1.46 g) as white crystals.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0eb558730a2845dfbe4f5090071f81a1
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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