Sulfuric Acid → HCID 22387896, compound

HRID 1699887Notes

Reaction equation

HRID 1699887 reaction equation
Cl.C(N[C:6]([C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][N:13]=[C:14]([CH3:27])[N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])=[CH:10][CH:9]=1)=[O:7])(=O)C.S(=O)(=O)(O)[OH:29]>O>[C:6]([C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][N:13]=[C:14]([CH3:27])[N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])=[CH:10][CH:9]=1)([OH:7])=[O:29]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22388411HCID 22388411, compound

Product 1

HCID 22387896HCID 22387896, compoundYield 38.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

To 7-(acetylcarbamoyl)-1-(2,4-dichlorobenzyl)-1,4-dihydro-2-methylquinazoline hydrochloride (0.46 g) were added water (1.2 g) and concentrated sulfuric acid (1.0 g) and the mixture was heated at 70° C. for 90 min. After cooling, ice was added and the precipitated solid was collected by filtration. The precipitate was washed with water and 2-propanol and dried to give the objective compound (0.145 g).

Workup

  1. temperatureAfter cooling
  2. additionice was added
  3. filtrationthe precipitated solid was collected by filtration
  4. washThe precipitate was washed with water and 2-propanol
  5. customdried

Sources & evidence

ORD record
ord-0c3c3ccf4a7c460caf1ed8f7379f43c7
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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