HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzonitrile → 4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile | HCID 11694705 | 71.2% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of p-aminobenzonitrile (2.00 g), Meldrum's acid (2.56 g), ethyl orthoformate (2.76 g) and ethanol (10 ml) was heated at 120° C. (bath temperature) to evaporate the ethanol. Ethyl acetate was added to the obtained orange solid. The solid was pulverized, collected by filtration and washed with ethyl acetate to give the object compound (3.28 g) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06348474B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-3d412e743780466e841877e60d7dc848 |
| Source note | uspto-grants-2002_02 |