反应详情

To 3-nitro-4-propylbenzoic acid (31.0 g) were added sulfuric acid (1.0 g) and methanol (300 ml) and the mixture was heated under reflux for 24 hr. After cooling, 5% Pd-C (0.60 g) was added to the reaction mixture and the mixture was stirred under a hydrogen atmosphere (normal pressure) for 6 hr. The reaction mixture was filtered through Celite and concentrated. To the residue was added a saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with toluene. The toluene layer was dried over sodium sulfate and concentrated to give the object compound (28.7 g) as an brown oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 24 hr
3. temperatureAfter cooling
4. filtrationThe reaction mixture was filtered through Celite
5. concentrationconcentrated
6. additionTo the residue was added a saturated aqueous sodium hydrogencarbonate solution
7. extractionthe mixture was extracted with toluene
8. dry with materialThe toluene layer was dried over sodium sulfate
9. concentrationconcentrated