Isobutyl iodide → 1-((tert-Butyldiphenylsilyloxy)methyl)-2-chloro-4-isobutylbenzene

HRID 1699907Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][Si:10]([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:4]([Cl:27])[CH:3]=1.[CH2:28](I)[CH:29]([CH3:31])[CH3:30]>>[Si:10]([O:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:3][C:4]=1[Cl:27])([C:23]([CH3:26])([CH3:25])[CH3:24])([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 10556Isobutyl iodide

HCID 22058631HCID 22058631, compound

Product 1

HCID 223882861-((tert-Butyldiphenylsilyloxy)methyl)-2-chloro-4-isobutylbenzene

Procedure

In the same manner as in Preparation Example 70-2, the objective compound (1.644 g, 76%) was obtained as a colorless oil from 4-bromo-1-((tert-butyldiphenylsilyloxy)methyl)-2-chlorobenzene and isobutyl iodide.

Workup

customIn the same manner as in Preparation Example 70-2

Sources & evidence

ORD record: ord-b80eec0c0dca4016b885457a01c5ecce
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06348474B1

Reaction notes

Loading…