Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-2-chloro-4-phenylbenzene | HCID 21938332 | — |
| Reactant | HCID 178497281 | HCID 178497281 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 22388096 | HCID 22388096 | 26.1% |
Reaction Steps
A mixture of 6-(methoxycarbonyl)-3-methyl-1H-indazole (1.90 g), 2-chloro-4-phenylbenzyl bromide (3.37 g), potassium carbonate (2.76 g), ethyl acetate(10 ml) and water (5 ml) was stirred for 14 hr at 70° C. Hexane and water were added, and the precipitated solid was collected by filtration and washed with a mixed solvent of ethyl acetate and hexane (2/3). This was dried under reduced pressure to give the objective compound (1.02 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06348474B1 |
|---|
| Source dataset | uspto-grants-2002_02 |
|---|
| ORD ID | ord-e5c2a5422df2475ebbb52260187c5425 |
|---|
| Source note | uspto-grants-2002_02 |
|---|
