Nitric Acid → 6-Nitrobenzothiazole

Participants

Reaction Steps

Nitration of 2-methylbenzothiazole was performed following the method of Mizuno (1952) J. Pharm. Soc. Japan 72:745. A mixture of fuming nitric acid (1.6 mL) and concentrated sulfuric acid (1.2 mL) was added to an ice-cooled solution of 2-methylbenzothiazole (2 g) in sulfuric acid (8 mL). The resulting solution was allowed to warm to room temperature for one hour, then poured onto 100 mL of ice. The resulting solid was filtered, washed with water, and recrystallized from ethanol (80 mL) to provide 2.5 g of 6-nitrobenzothiazole (1) in the form of yellowish needles.

Provenance & Evidence