Citric Acid → 5-Heptyl-2-oxo-tetrahydro-furan-3-carboxylic acid methylester

Participants

Reaction Conditions

Reaction Steps

To a mixture of 203 g 5-heptyl-dihydro-furan-2-one and 390 g dimethylcarbonate was slowly added 40 g of sodium hydride. The temperature increased to 65° C. After the temperature returned to room temperature, the reaction mixture was poured into saturated citric acid and extracted with hexane. The organic layer was dried and evaporated to dryness. The residue was distilled to yield 150.5 g of a colourless liquid.

Provenance & Evidence