HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1700000Generated: November 1, 2026
Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene
https://huagongshe.com/reaction/1700000
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-2,6-difluorophenol | HCID 18371110 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Bromo-2,4-difluoro-3-methoxybenzene | HCID 18371109 | — |
Reaction Steps
A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06348624B1 |
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| Source dataset | uspto-grants-2002_02 |
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| ORD ID | ord-24f5c5162f5c49bf8082deba94f9f7e7 |
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| Source note | uspto-grants-2002_02 |
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