HuagongsheHuagongshe Chemistry Print Report · For research reference only
Z-Asp(OtBu)-Leu-OBzl → H-Asp(OtBu)-Leu-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Z-Asp(OtBu)-Leu-OBzl | HCID 131721133 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | H-Asp(OtBu)-Leu-OH | HCID 131721134 | 89.7% |
Reaction Steps
The Z-Asp(OtBu)-Leu-OBzl (15.6 g) in methanol (50 mL) was added 10% Pd on carbon (0.17 g) and was hydrogenated on a Paar Shaker. After filtering off the catalyst, the filtrate was concentrated to give a foamy solid. The crude product was triturated with diethyl ether to yield 8.03 g of H-Asp(OtBu)-Leu-OH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06350573B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-d8949fc92e254a88bade9298a099055a |
| Source note | uspto-grants-2002_02 |