HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1700079Generated: October 25, 2026
Dicyclohexylcarbodiimide → N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester
https://huagongshe.com/reaction/1700079
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Leucine, N-carboxy-, N-benzyl ester, L- | HCID 74840 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester | HCID 11089751 | — |
Reaction Steps
Z-Leu-OH (15.92 g) and N-hydroxysuccinimide (6.9 g) were dissolved in dioxane and cooled to 0° C. To the cooled solution, DCC was added and stirred at 0° C. for 0.5 h, then room temp overnight. After filtering off the byproduct urea, the filtrate was concentrated to give crude Z-Leu-OSu as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06350573B1 |
|---|
| Source dataset | uspto-grants-2002_02 |
|---|
| ORD ID | ord-1adfcd0ac5ff4986b356e0f25a2c428b |
|---|
| Source note | uspto-grants-2002_02 |
|---|
