Ammonia → HCID 59875466, compound

Participants

Reaction Steps

A solution of (2R,3R,4R,5R)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-{2-cyano-6-[(1-naphthylmethyl)amino]-9H-purin-9-yl}tetrahydro-3-furanyl acetate (3.5 g, 6.27 mmol) (Preparation 13) in ethanol (120 ml) was saturated with ammonia gas and stirred at room temperature for 4 days. The solvent was removed under reduced pressure and the residue was triturated with water (100 mls), filtered and dried to afford the title compound as a solid (2.4 g).

Provenance & Evidence