1,2-Dichloroethane → HCID 69540415, compound

Participants

Reaction Steps

To a solution of 13a and 3,5-dimethyl-4-hydroxybenzoic acid (307 mg, 1.85 mmol) in 5 ml each of DMF and CH2Cl2 was added HOBT (250 mg, 1.85 mmol), EDC (421 mg, 2.2 mmol), and triethylamine (0.64 ml, 4.56 mmol). The reaction was stirred at room temp. for 18 hrs. then diluted with EtOAc (150 ml) and washed with 10% NaHSO4, sat. NaHCO3 and sat. NaCl. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated in vacuo to afford a gum that was purified by flash chromatography eluting with CH2Cl2/EtOAc (7/3) to afford 545 mg (62%) of the title compound.

Provenance & Evidence