Isoquinoline-1-carboxylic acid → HCID 22948701, compound
Reaction equation
[O:1]=[C:2]1[C@@H:8]([NH:9][C:10](=[O:20])C2C=C(C)C(O)=C(C)C=2)[CH2:7][C:6](=[O:21])[C:5]2[CH:22]=[CH:23][CH:24]=[CH:25][C:4]=2[N:3]1[CH2:26][C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28].[C:37]1(C(O)=O)[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=[CH:39][N:38]=1>>[O:1]=[C:2]1[C@@H:8]([NH:9][C:10]([C:37]2[C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH:40]=[CH:39][N:38]=2)=[O:20])[CH2:7][C:6](=[O:21])[C:5]2[CH:22]=[CH:23][CH:24]=[CH:25][C:4]=2[N:3]1[CH2:26][C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28]Participants
3
Procedure
Was prepared by the method reported in 14a by reaction of 12 and isoquinoline-1-carboxylic acid to afford 930 mg (92%) of the title compound.
Workup
- customWas prepared by the method
Sources & evidence
- ORD record
- ord-26610f4798614d2caf6a6625f0a8c1a7
- Source dataset
- uspto-grants-2002_02
- Patent number
- US06350741B1
Reaction notes
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