Hydrochloric Acid → HCID 18317251, compound

Participants

Reaction Steps

Under Ar, a solution of 29 (0.3 g, 0.47 mmol) in 30% HBr-AcOH (5 mL) was stirred at room temperature for 1 h. The reaction was then treated with 2N HCl and extracted with Et2O (2×). The resulting aqueous was then basified with saturated Na2CO3 and extracted with EtOAc (3×). The organic extracts were dried, filtered and concentrated to dryness. The residue was chromatographed on a Still column (40 mm) and the product eluted with 5% CH3OH CHCl3 saturated with NH3 to yield 70 mg of 30.

Provenance & Evidence