HCID 18317237, compound → HCID 9929959, compound

Participants

Reaction Steps

Under Ar, a mixture of 35 (0.68 g, 1.3 mmol) and 30% HBr—AcOH (10 mL) was stirred at room temperature. After 3 h, 3N HCl (50 mL) was added and the solution extracted with Et2O (2×). The aqueous layer was basified with saturated Na2CO3 and extracted with EtOAc (6×). The organic extracts were dried, filtered and concentrated to dryness. The residue was crystallzed from EtOAc-hexanes to yield 73 mg (15%) of 36 mp 148-50° C.

Provenance & Evidence