Acetic Acid → HCID 178509842, compound

HRID 1700148Notes

Reaction equation

HRID 1700148 reaction equation
[CH2:1]1[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[NH:3][C:2]1=[O:14])[N:10]=[CH:9][CH:8]=[CH:7]3.[NH2:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20].[C:24](O)(=O)C>>[O:14]=[C:2]1[NH:3][C:4]2[C:5](=[C:6]3[C:11](=[CH:12][CH:13]=2)[N:10]=[CH:9][CH:8]=[CH:7]3)/[C:1]/1=[CH:24]/[NH:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 167023-AminobenzonitrileHCID 219070851,3-Dihydro-pyrrolo[3,2-f]quinoline-2-one

Product 1

HCID 178509842HCID 178509842, compoundYield 78%

Procedure

Prepared from the dimethylaminomethylene derivative (Procedure E) of 1,3-dihydro-2H-pyrrolo[3,2-f]quinolin-2-one (Procedure C) with 3-aminobenzonitrile according to Procedure G in acetic acid to give the title compound in 78% yield as the acetate salt.

Sources & evidence

ORD record
ord-e8ccf8403c2c4b34a9df61a56ffbd756
Source dataset
uspto-grants-2002_02
Patent number
US06350747B1

Reaction notes

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