Acetic Acid → HCID 178492231, compound

HRID 1700149Notes

Reaction equation

HRID 1700149 reaction equation
[CH2:1]1[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[NH:3][C:2]1=[O:14])[N:10]=[CH:9][CH:8]=[CH:7]3.[CH3:15][O:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1.[C:24](O)(=O)C>>[CH3:15][O:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21]/[CH:24]=[C:1]2\[C:2](=[O:14])[NH:3][C:4]3[C:5]\2=[C:6]2[C:11](=[CH:12][CH:13]=3)[N:10]=[CH:9][CH:8]=[CH:7]2)=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 7732P-AnisidineHCID 219070851,3-Dihydro-pyrrolo[3,2-f]quinoline-2-one

Product 1

HCID 178492231HCID 178492231, compoundYield 54%

Procedure

Prepared from the dimethylaminomethylene derivative (Procedure E) of 1,3-dihydro-2H-pyrrolo[3,2-f]quinolin-2-one (Procedure C) with 4-methoxyaniline according to Procedure G in acetic acid to give the title compound in 54% yield as the acetate salt.

Sources & evidence

ORD record
ord-0c6266fb1ad340c58f8227023dc45bf7
Source dataset
uspto-grants-2002_02
Patent number
US06350747B1

Reaction notes

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