反应详情

温度

0 °C

N-{3-[4-(4-Cyano-3-fluoro-phenyl)-3-methyl-3,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-3-oxo-propyl}-3-methoxy-benzenesulfonamide (0.05 g, 0.100 mmol), prepared as described in Step H, was dissolved in CH2Cl2 (2 mL) and cooled to 0° C. A 1M solution of BBr3 in CH2Cl2 (2.0 mL, 2.00 mmol) was added dropwise via syringe and stirred for 4 h. The reaction mixture was diluted with CH2Cl2 and saturated NaHCO3 solution and separated. The aqueous layer was washed with CH2Cl2 (2×), the organic layers combined, dried (Na2SO4), filtered and concentrated to give the title compound.

1. customseparated
2. washThe aqueous layer was washed with CH2Cl2 (2×)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated